November 2025– date –

In Parts 1 and 2, we introduced CDK7 and CDK8 in transcription initiation. Here in Part 3, we focus on CDK9, the central kinase controlling the transition from paused RNA polymerase II (Pol II) to productive elongation. Among transcripti...

In Part 1, we reviewed the fundamentals of transcription and the CDK family. In this article, we focus on CDK7 and CDK8, two kinases that act at the transcriptional “starting line.” While both regulate initiation, their roles and drug di...

This series focuses on the transcriptional machinery as an emerging target for cancer therapy, highlighting CDK (Cyclin-Dependent Kinases) families involved in transcription and BRD4. While CDK4/6 inhibitors have already transformed onco...

This series will explore the latest drug discovery trends targeting the transcriptional machinery. In Part 1, we provide an introduction: what transcription is, how CDKs regulate it, and why transcriptional CDKs are emerging as hot targe...

On November 6, 2025, the U.S. Food and Drug Administration (FDA) approved Darzalex Faspro (daratumumab and hyaluronidase-fihj, Janssen Biotech, Inc.) for the treatment of adults with high-risk smoldering multiple myeloma (SMM). This mark...

What’s Next — GDF15 Blockade and the Era of Precise Phenotypes Our finale focuses on near-future therapies and trial design. Beyond “weight,” we target phenotype × mechanism and build evidence that actually changes care. 3 takeaways Dire...

What Works Today — Nutrition, Exercise, Anti-inflammation, and Current Drugs Part 5 is a how-to guide. We align home and clinic workflows and run nutrition, resistance exercise, inflammation/symptom control as a package. Medications are ...

What Breaks in CAC? — Human Evidence on Appetite, Metabolism, Fat & Muscle In Part 4 we look behind the scenes using human data: central appetite circuits, systemic metabolism, adipose tissue, and skeletal muscle. We map these mechan...

Making CAC Visible — Phenotyping with CT, Function, and PROs Part 3 is a practical guide to phenotyping in clinic. Combine CT body composition, simple functional tests, and patient-reported outcomes (PROs) to sort patients into actionabl...

Don’t Miss It — Home & Clinic Checklists + FAQs Part 2 is a hands-on template pack. Use these copy-and-paste formats for two-week home monitoring and quick clinic checks so patients, families, and clinicians can share the same langua...

What Is CAC? — The Disease You Can’t See by Weight Alone This is a “super-basic” primer for patients, families, and general readers. We minimize jargon and focus on signs you can notice at home and what to bring to clinic visits. Why wei...