Organoid– tag –
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Enteric neuron–gastric cancer organoids expose lipid-metabolic Achilles’ heels — Strengths and limits of organoids for drug discovery, and what comes next
In a nutshell: Genome-wide CRISPR screens in patient-derived gastric cancer organoids uncovered strong dependencies on fatty-acid biosynthesis (ACC/ACACA) and cholesterol biosynthesis (LSS). Co-culture with enteric neurons (ENS) rewires ... -
Rare & Pediatric Disease News Vol.4: Organoid-Based Discovery for UBA5-Linked Pediatric Epileptic Encephalopathy
Screenshot Human Brain Organoids Reveal Therapeutic Potential for Rare Pediatric Epilepsy In June 2025, a research team led by Dr. Heather Mefford at St. Jude Children’s Research Hospital reported a groundbreaking study using human brain...
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