Biotech Investment News: Novo Nordisk’s Major Deals from 2015 to 2025

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Strategic Overview: Expanding from Diabetes to Obesity, RNA, and Cardiometabolic Disease

Novo Nordisk, known for its leadership in GLP-1 receptor agonists (Ozempic, Wegovy), has expanded significantly over the past decade. Through acquisitions and R&D alliances, it has embraced RNA-based drugs, cardiovascular, liver, and rare diseases—beyond its historical diabetes focus.

Key Acquisitions and Collaborations (2015–2025)

  • 2015: Calibrium and MB2 (GLP-1 R&D spin-outs from Indiana University)
  • 2018: Ziylo (glucose-responsive insulin tech – UK)
  • 2020: Corvidia Therapeutics (RNA for CVD/CKD) – ~$2.2B
  • 2021: Emisphere Technologies (oral peptide delivery) – ~$1.8B
  • 2022: Dicerna Pharmaceuticals (RNAi therapeutics) – ~$3.3B
  • 2023: Forma Therapeutics (sickle cell, rare hematology) – ~$1.1B
  • 2023: Inversago Pharma (CB1 inhibitors for obesity/NASH) – up to ~$1.4B
  • 2024: Cardior Pharmaceuticals (RNA heart failure therapy) – ~$1.1B
  • 2025: Deep Apple (small molecule GPCR platform) – $812M
  • 2025: Gensaic (precision protein drug collaboration) – $354M
  • 2025: Septerna (oral obesity and diabetes collaboration)
  • 2025: AI drug discovery partnership with NVIDIA and DCAI

Strategic Insight

Novo Nordisk is no longer just a diabetes giant. It is expanding its innovation platform into RNA therapeutics and AI discovery. Its investments in Cardior, Gensaic, and NVIDIA collaborations show a forward-thinking approach beyond GLP-1.

My Insight

While Novo Nordisk remains dominant in GLP-1 therapies, its recent portfolio moves signal long-term diversification. Its strategic entries into RNA and AI-enabled platforms will define its relevance in the next decade of metabolic and precision medicine.

References

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Author of this article

After completing graduate school, I studied at a Top tier research hospital in the U.S., where I was involved in the creation of treatments and therapeutics in earnest. I have worked for several major pharmaceutical companies, focusing on research, business, venture creation, and investment in the U.S. During this time, I also serve as a faculty member of graduate program at the university.

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