Science News– category –
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🧬 Unraveling Insulin Resistance and Type 2 Diabetes with Personalized Molecular Maps: The Power of Proteomics and Genomics
Why do some people develop diabetes while others with similar lifestyles don’t?The answer may lie in your molecular fingerprint. This article summarizes groundbreaking findings from a recent Cell (July 2025) paper and integrates insights... -
Arsenic Life and the Cost of Scientific Integrity: A 15-Year Retraction from Science
■ Introduction In July 2025, the prestigious journal Science officially retracted a paper it had published in 2010, claiming the discovery of a bacterium that could substitute arsenic for phosphorus in its DNA. Known as the “arsenic life... -
[Science News] Cancer Discovery Perspective: Restoring Tumor Suppressor Function of Mutant p53 via Small Molecules
A study published in the June 2025 issue of Cancer Discovery reports a novel small-molecule strategy to restore the tumor suppressor function of mutant p53 proteins. This work was also featured in a companion Perspective article, highlig... -
[Science News] Cancer Discovery Spotlight: CAFs Suppress NK Cells to Promote Breast Cancer Metastasis
A study published in the June 2025 issue of Cancer Discovery reveals how cancer-associated fibroblasts (CAFs) promote metastatic progression in breast cancer by suppressing natural killer (NK) cell cytotoxicity. This work was selected fo... -
[Science News] KRAS Inhibition and T-cell Dependency: Defining the Immune Role in Pancreatic Cancer Therapy (Cancer Discovery Summary / With My Thoughts)
A study published online in June 2025 in Cancer Discovery reveals that **T-cell–dependent tumor regression** is a key mechanism underlying the efficacy of KRAS G12D inhibitors in pancreatic ductal adenocarcinoma (PDAC). KRAS G12D is a ma... -
[Science News] Long-Term Latency of Highly Mutated Cells in Esophageal Squamous Cell Carcinoma: Cancer Discovery Summary (With My Thoughts)
A study published in the June 2025 issue of Cancer Discovery reveals that highly mutated cell clones carrying multiple driver mutations can persist for many years in esophageal squamous epithelium before progressing to esophageal squamou... -
[Science News] Cell Leading Edge: Reversible Transcriptome Remodeling Controls Cellular Quiescence Entry and Exit
A study published in the June 2025 issue of Cell reveals how dynamic transcriptome remodeling orchestrates both entry into and exit from cellular quiescence. This article was selected for the journal's prominent Leading Edge feature, hig... -
[Science News] Nature Highlight: Small Molecules Restore Mutant Mitochondrial DNA Polymerase Activity
A new study published in the June 12, 2025 issue of Nature reports that the small molecule PZL-A can directly restore the function of DNA polymerase gamma (POLγ), impaired by POLG mutations causing severe mitochondrial disorders. This wo... -
[Science News] Nuclear Pore Complex Dysfunction Underlies ALS/FTD via C9orf72 Mutations: Nature Summary (With My Thoughts)
A U.S. research team has revealed that repeat expansions in the C9orf72 gene — a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) — induce dysfunction of the nuclear pore complex (NPC) in neurons. In C...
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