Science News– category –

Even after successful primary treatment, disseminated cancer cells (DCCs) can persist in a dormant state for years and later “awaken,” leading to overt metastasis. Recent studies suggest that respiratory viral infections—such as influenz...

Across pancreatic ductal adenocarcinoma (PDAC) models, tumor cells show marked intercellular heterogeneity in stress granules (SGs). A single-cell, cell-cycle–aware view reveals that SGs are maximally enriched in G2, powered by a lipid m...

Paper: A fluorescent-protein spin qubit (Nature, 4 Sep 2025) In a nutshell Enhanced yellow fluorescent protein (EYFP) is realized as an optically addressable spin qubit supporting initialization, readout, and coherent control. At liquid-...

Lead: Kidneys are prone to hypoxia, fueling AKI-to-CKD progression. A 2025 Science study shows that a hypoxia-induced “tRNA-Asp-GTC-3′tDR” safeguards kidney cells by maintaining autophagic flux through RNA autophagy. This adds a new laye...

In recent years, cancer and aging have increasingly been understood not as separate biological phenomena, but as interconnected processes. Immune decline and chronic inflammation in cancer patients may not be caused solely by treatment s...

Appendix: IL-6R Inhibitors & Company Landscape (as of Aug 2025) A quick map of who owns which IL-6R blockers and current approved uses, to inform combo trials and partnering around the neuro-immune loop discussed above. Approved agen...

Fresh data in Science Signaling (2025) show that tumor-derived small extracellular vesicles (sEVs) reprogram TRPV1+ nociceptors, boosting IL-6 and Substance P, thereby increasing MDSC infiltration and CD8 T-cell exhaustion—a neuro-immune...

Recent research highlights that aging and obesity each independently promote cancer progression and can act synergistically to worsen outcomes. However, weight loss appears capable of rejuvenating immune function and suppressing tumor gr...

Introduction The blood-brain barrier (BBB) and blood-retina barrier (BRB) are essential for maintaining the homeostasis of the central nervous system (CNS). They selectively allow the passage of nutrients and hormones while blocking toxi...

Even with solved structures, folding thermodynamics (ΔG) has long been hard to see. Recent work closes this gap with mega-scale measurements and a simple scheme—additive energy models with sparse pairwise couplings. This article connects...

Why do some people develop diabetes while others with similar lifestyles don’t?The answer may lie in your molecular fingerprint. This article summarizes groundbreaking findings from a recent Cell (July 2025) paper and integrates insights...

■ Introduction In July 2025, the prestigious journal Science officially retracted a paper it had published in 2010, claiming the discovery of a bacterium that could substitute arsenic for phosphorus in its DNA. Known as the “arsenic life...

A study published in the June 2025 issue of Cancer Discovery reports a novel small-molecule strategy to restore the tumor suppressor function of mutant p53 proteins. This work was also featured in a companion Perspective article, highlig...

A study published in the June 2025 issue of Cancer Discovery reveals how cancer-associated fibroblasts (CAFs) promote metastatic progression in breast cancer by suppressing natural killer (NK) cell cytotoxicity. This work was selected fo...

A study published online in June 2025 in Cancer Discovery reveals that **T-cell–dependent tumor regression** is a key mechanism underlying the efficacy of KRAS G12D inhibitors in pancreatic ductal adenocarcinoma (PDAC). KRAS G12D is a ma...

A study published in the June 2025 issue of Cancer Discovery reveals that highly mutated cell clones carrying multiple driver mutations can persist for many years in esophageal squamous epithelium before progressing to esophageal squamou...

A study published in the June 2025 issue of Cell reveals how dynamic transcriptome remodeling orchestrates both entry into and exit from cellular quiescence. This article was selected for the journal's prominent Leading Edge feature, hig...

A new study published in the June 12, 2025 issue of Nature reports that the small molecule PZL-A can directly restore the function of DNA polymerase gamma (POLγ), impaired by POLG mutations causing severe mitochondrial disorders. This wo...

A U.S. research team has revealed that repeat expansions in the C9orf72 gene — a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) — induce dysfunction of the nuclear pore complex (NPC) in neurons. In C...