Science News– category –

At SABCS 2025, multimodal AI (ICM+ model) outperforms Oncotype DX for 15-year recurrence prediction (C-index 0.733 vs 0.631). Final volume of our series.

Spain's AITIC trial (Nature Medicine 2026, n=31,301): partially autonomous AI workflow cuts radiologist workload 63.6%, lifts detection 15.2%. Vol. 2.

Sweden's MASAI trial (Lancet 2026, n>105,000) shows AI mammography cuts interval cancers by 12% and lifts sensitivity to 80.5%. Vol. 1 of our series.

Brain tumors sit at the crossroads of immunology and microbiology, but they are also a uniquely challenging environment to study. Brain tumors sit at the crossroads of immunology and microbiology, but they are also a uniquely challenging...

This post explains, in plain language, why pan-cancer (comprehensive) analyses and atlas databases matter in oncology, and how the concept of microbial signatures fits into that bigger picture. As a short preface to the series, we also t...

Respiratory viral infections may silently reshape metastatic risk in breast cancer survivors. Recent epidemiology and mechanistic studies converge on a practical question: what should clinicians change tomorrow morning? Here is the evide...

Across pancreatic ductal adenocarcinoma (PDAC) models, tumor cells show marked intercellular heterogeneity in stress granules (SGs). A single-cell, cell-cycle–aware view reveals that SGs are maximally enriched in G2, powered by a lipid m...

Paper: A fluorescent-protein spin qubit (Nature, 4 Sep 2025) What you will learn In a nutshellWhat’s novel?How it works (OADF/ODMR)Key resultsWhy it matters In a nutshell Enhanced yellow fluorescent protein (EYFP) is realized as an optic...

Lead: Kidneys are prone to hypoxia, fueling AKI-to-CKD progression. A 2025 Science study shows that a hypoxia-induced “tRNA-Asp-GTC-3′tDR” safeguards kidney cells by maintaining autophagic flux through RNA autophagy. This adds a new laye...

In recent years, cancer and aging have increasingly been understood not as separate biological phenomena, but as interconnected processes. Immune decline and chronic inflammation in cancer patients may not be caused solely by treatment s...

Appendix: IL-6R Inhibitors & Company Landscape (as of Aug 2025) A quick map of who owns which IL-6R blockers and current approved uses, to inform combo trials and partnering around the neuro-immune loop discussed above. What you will...

Fresh data in Science Signaling (2025) show that tumor-derived small extracellular vesicles (sEVs) reprogram TRPV1+ nociceptors, boosting IL-6 and Substance P, thereby increasing MDSC infiltration and CD8 T-cell exhaustion—a neuro-immune...

Recent research highlights that aging and obesity each independently promote cancer progression and can act synergistically to worsen outcomes. Recent research highlights that aging and obesity each independently promote cancer progressi...

Introduction The blood-brain barrier (BBB) and blood-retina barrier (BRB) are essential for maintaining the homeostasis of the central nervous system (CNS). The blood-brain barrier (BBB) and blood-retina barrier (BRB) are essential for m...

Even with solved structures, folding thermodynamics (ΔG) has long been hard to see. Even with solved structures, folding thermodynamics (ΔG) has long been hard to see. Recent work closes this gap with mega-scale measurements and a simple...

Why do some people develop diabetes while others with similar lifestyles don’t?The answer may lie in your molecular fingerprint. This article summariz Why do some people develop diabetes while others with similar lifestyles don’t?The ans...

■ Introduction In July 2025, the prestigious journal Science officially retracted a paper it had published in 2010, claiming the discovery of a bacterium that could substitute arsenic for phosphorus in its DNA. In July 2025, the prestigi...

A study published in the June 2025 issue of Cancer Discovery reports a novel small-molecule strategy to restore the tumor suppressor function of mutant p53 proteins. A study published in the June 2025 issue of Cancer Discovery reports a ...

A study published in the June 2025 issue of Cancer Discovery reveals how cancer-associated fibroblasts (CAFs) promote metastatic progression in breast A study published in the June 2025 issue of Cancer Discovery reveals how cancer-associ...

A study published online in June 2025 in Cancer Discovery reveals that **T-cell–dependent tumor regression** is a key mechanism underlying the efficacy of KRAS G12D inhibitors in pancreatic ductal adenocarcinoma (PDAC). KRAS G12D is a ma...