A study published in the June 2025 issue of Cell reveals how dynamic transcriptome remodeling orchestrates both entry into and exit from cellular quiescence. This article was selected for the journal’s prominent Leading Edge feature, highlighting its scientific significance.
Using fibroblasts as a model, the research team conducted time-resolved analyses of transcriptional changes during cell cycle arrest and quiescence induction. They identified a two-phase mechanism: an initial transient transcriptional downregulation followed by stable low-activity maintenance. Upon exit from quiescence, rapid transcriptional reactivation enables re-entry into the cell cycle.
These findings provide a foundational framework for understanding quiescence regulation in contexts ranging from tissue stem cell maintenance to cancer dormancy and aging research.
Source: Cell (June 2025), Article Link (Leading Edge: Feature Link)
【My Thoughts】
Cellular quiescence is deeply involved in both physiological tissue homeostasis and pathological states such as cancer relapse. This comprehensive transcriptional framework offers valuable insights that may support future therapeutic strategies targeting quiescence regulation in drug development and regenerative medicine.
Comments