Chronic disease– tag –

Introduction: A Map of Aging × Cancer Is Starting to Emerge In this final article of the Expert Series, we step back to ask: Where is aging and cancer research heading over the next 10–20 years? How might these developments change clinic...

Introduction: Why “Young” Models Struggle to Capture “Old” Cancer Throughout this Expert Series we have discussed: Epigenetic clocks and ImAge as tools to visualize aging Tissue- and genotype-specific aging profiles How lymphoma and canc...

Introduction: The Gap Between Aging Biology and Everyday Oncology In earlier parts of this Expert Series, we have explored: Epigenetic clocks and ImAge as tools to quantify “how old” tissues and cells are Tissue- and genotype-specific pr...

Introduction: Adding Lifestyle and Environment to the Genetics–Aging Framework In previous parts of this Expert Series, we focused primarily on “internal” factors: Epigenetic clocks and ImAge as tools to visualize aging Tissue- and genot...

Introduction: Questioning the Dogma that “Aging = More Cancer” In previous parts of this Expert Series, we have discussed: Tools such as epigenetic clocks and ImAge to “visualize” aging Tissue-specific aging profiles and genetic backgrou...

Introduction: Why It Is Hard to Model Aging and Cancer Together In earlier parts of this Expert Series, we have discussed: Tools to visualize aging (epigenetic clocks, single-cell profiling, image-based metrics) Tissue-specific aging pro...

Introduction: Reproductive Aging as a Hub Between Women’s Aging and Cancer In Parts 1–3 of the Expert Series, we discussed: Tools to “visualize” aging (epigenetic clocks, single-cell profiles, image-based metrics) Tissue-specific aging p...

Introduction: Beyond “Aging → Cancer” to “Cancer → Aging” In the Introductory and earlier Expert Series articles, we mainly focused on the direction: Aging increases the risk of cancer Tissue- and genotype-specific aging patterns shape w...

Introduction: Aging Is Not Uniform Across the Body In Part 1 of the Expert Series, we focused on “making aging visible” through epigenetic clocks, single-cell analyses, and image-based metrics. We saw that people of the same chronologica...

Introduction: From the Introductory Series to the Expert Series In the Introductory Series (Parts 1–7), we approached the relationship between aging and cancer from multiple angles—historical, molecular, immunologic, organ-level, lifesty...

Introduction: Screening Is Not Just “The Earlier, the Better” In Parts 1–5, we explored the relationship between aging and cancer from multiple angles: molecular and genetic mechanisms, immune aging, organ-specific aging profiles, and li...

Introduction: Deconstructing Risk Factors In Parts 1–4 of this series, we explored aging and cancer from several angles: Time and historical concepts Molecular and genetic mechanisms Immune aging and the tumor microenvironment Organ- and...

Introduction: The Triangle of Aging, Cancer, and Immunity In Part 1, we explored why cancer is often described as a “disease of aging” and reviewed the historical and conceptual overlap between the hallmarks of aging and the hallmarks of...

Introduction: Zooming in on the “Inner Structure” of Aging In Part 1, we asked why cancer is often called a “disease of aging” and reviewed how the hallmarks of aging and the hallmarks of cancer overlap. We moved beyond the simple idea t...

Introduction: Why Revisit “Aging and Cancer” Now? The phrase “cancer is a disease of aging” is something most clinicians and life science professionals have heard countless times. Yet very few of us have had the chance to carefully organ...

Lead: Kidneys are prone to hypoxia, fueling AKI-to-CKD progression. A 2025 Science study shows that a hypoxia-induced “tRNA-Asp-GTC-3′tDR” safeguards kidney cells by maintaining autophagic flux through RNA autophagy. This adds a new laye...