The Window Where Cancer Is Born — Progenitor Niche and the Benign-to-Malignant Transition | Frontiers of Cancer Origin Research, Vol. 1
Reyes et al. Cell May 2026: PDAC's benign-to-malignant transition happens in a rare progenitor-like cell population that assembles a self-reinforcing niche. Tumor-driving and tumor-suppressing programs (p53, CDKN2A, SMAD4) co-activate in these cells. KRAS inhibition or p53 activation collapses the niche and delays malignancy. Vol. 1.
