What Cerebellar Organoids Reveal About Medulloblastoma’s Origin: 3 Axes Toward Precision Medicine | Cancer Origin Vol.2
Cell April 2026 paper used human iPSC-derived cerebellar organoids + CRISPR to reproduce all four medulloblastoma subtypes (WNT, SHH, Group 3, Group 4) in real time. Cell of origin for each subtype directly confirmed. Vismodegib and BET inhibitor responses validated in subtype-specific manner. Personalized-therapy organoid proof of concept. Vol. 2.
