FMT Is Subtraction, Not Addition — How FMT-LUMINate Dissected the Real Mechanism Behind Microbiome-Empowered Cancer Immunotherapy | Making Cancer Immunotherapy Work with FMT, Vol. 2
Building on Volume 1, we dissect the convergent finding across the three April 2026 Nature Medicine trials: FMT works because patients lose their own deleterious bacteria, not because they acquire donor bacteria. FMT-LUMINate's mouse reverse-experiment proved causality. Mechanism: tryptophan/kynurenine pathway disturbance, IDO/AhR axis, regulatory T-cell expansion. Vol. 2 of the series.